Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Perineurial control of metabolism Ana I. Domingos Recommendations for mitochondria transfer and transplantation nomenclature and characterization This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation. Jonathan R. Brestoff Keshav K. Singh Minghao Zheng Consensus Statement 16 Jan 2025 Recommendations for mitochondria transfer and transplantation nomenclature and characterization This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation. Jonathan R. Brestoff Keshav K. Singh Short-chain fatty acids This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases. Aygul Dagbasi Mingzhu Cai Gary Frost Review Article 29 Jul 2026 Short-chain fatty acids This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases. Adiposity and cancer: epidemiology, mechanisms and future perspectives This Review discusses epidemiological trends for adiposity and cancer and summarizes mechanisms linking obesity to cancer development. Eleanor L. Watts Amparo Gonzalez-Feliciano Steven C. Moore Review Article 15 Jun 2026 Adiposity and cancer: epidemiology, mechanisms and future perspectives This Review discusses epidemiological trends for adiposity and cancer and summarizes mechanisms linking obesity to cancer development. Eleanor L. Watts Amparo Gonzalez-Feliciano Steven C. Moore Adiposity and cancer: systematic review and meta-analysis In a meta-analysis including 1.5 million incidences of cancer, positive associations between body mass index and 19 cancers were identified, underlining the impact of obesity on cancer risk. Eleanor L. Watts Amparo Gonzalez-Feliciano Steven C. Moore Article Open Access 15 Jun 2026 Adiposity and cancer: systematic review and meta-analysis In a meta-analysis including 1.5 million incidences of cancer, positive associations between body mass index and 19 cancers were identified, underlining the impact of obesity on cancer risk. Eleanor L. Watts Amparo Gonzalez-Feliciano Steven C. Moore Polyendocrine metabolic ovarian syndrome — a new name for an old problem Pawel Kordowitzki Helena Teede Comment 03 Jun 2026 Polyendocrine metabolic ovarian syndrome — a new name for an old problem Pawel Kordowitzki Metabolism as the biochemical language for mechanistic biomedical AI Li Li Yujue Wang Zeping Hu Comment 04 Jun 2026 Metabolism as the biochemical language for mechanistic biomedical AI Exercise and glucagon-like peptide 1 receptor agonists in cardiovascular disease beyond weight loss Alex J. Jordan Michael McDermott News & Views 24 Jun 2026 Exercise and glucagon-like peptide 1 receptor agonists in cardiovascular disease beyond weight loss Michael McDermott Mitochondrial quality control in human ageing and longevity Anna Picca Luigi Ferrucci Review Article 29 Jun 2026 Mitochondrial quality control in human ageing and longevity Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial Rasmus Michael Sandsdal Joachim Holt Signe Sørensen Torekov Brief Communication Open Access 24 Jun 2026 Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial Rasmus Michael Sandsdal Signe Sørensen Torekov Association of GLP-1RA discontinuation and risk of depressive and anxiety disorders in people with type 2 diabetes: a cohort study Tingyu Zhang Ping He Guang Ning Brief Communication 09 Jul 2026 Association of GLP-1RA discontinuation and risk of depressive and anxiety disorders in people with type 2 diabetes: a cohort study Collection on Obesity Nature Metabolism participates in this collection together with other journals across the Nature Portfolio.This collection welcomes the submission of clinical and preclinical work that explores all aspects of obesity, including causes, pathophysiological mechanisms, incidence, and impact, as well as approaches to prevent or treat obesity, such as GLP-1 agonists alone or in combination therapies. Collection on Obesity Nature Metabolism participates in this collection together with other journals across the Nature Portfolio.This collection welcomes the submission of clinical and preclinical work that explores all aspects of obesity, including causes, pathophysiological mechanisms, incidence, and impact, as well as approaches to prevent or treat obesity, such as GLP-1 agonists alone or in combination therapies. Early-stage investigators share their stories The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors. Early-stage investigators share their stories The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors. Collection on Muscle Biology Nature Metabolism participates in this collection together with other journals across the Nature Portfolio. This collection welcomes submissions on myogenesis, muscle metabolism, muscle regeneration and response to exercise, as well as muscle wasting in the context of ageing and cachexia. Open for submissions Collection on Muscle Biology Nature Metabolism participates in this collection together with other journals across the Nature Portfolio. This collection welcomes submissions on myogenesis, muscle metabolism, muscle regeneration and response to exercise, as well as muscle wasting in the context of ageing and cachexia. Improving reproducibility of metabolic research This Collection of articles, published in Nature Metabolism, aims to highlight best practices in experimental design, analysis and reporting to support the metabolic research community and increase reproducibility of research in the life sciences. Improving reproducibility of metabolic research This Collection of articles, published in Nature Metabolism, aims to highlight best practices in experimental design, analysis and reporting to support the metabolic research community and increase reproducibility of research in the life sciences. Latest Research articles Parabrachial neurons orchestrate cold-induced homeostatic responses Using activity-dependent genetic labelling in mice, the authors identify cold-activated neurons in the parabrachial nucleus that coordinate autonomic, metabolic, behavioural and affective adaptations to cold exposure. Sieun Jung Anna Kondaurova Sung-Yon Kim Letter 13 Aug 2026 Parabrachial neurons orchestrate cold-induced homeostatic responses Using activity-dependent genetic labelling in mice, the authors identify cold-activated neurons in the parabrachial nucleus that coordinate autonomic, metabolic, behavioural and affective adaptations to cold exposure. Anna Kondaurova Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour DHHC17-mediated palmitoylation promotes laminin-511 stabilization and availability in the liver metastatic niche, which decreases the cancer cell-killing capacity of neutrophils. Anke Vandekeere Juan Fernández-García Sarah-Maria Fendt Article 05 Aug 2026 Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour DHHC17-mediated palmitoylation promotes laminin-511 stabilization and availability in the liver metastatic niche, which decreases the cancer cell-killing capacity of neutrophils. Anke Vandekeere Juan Fernández-García Sarah-Maria Fendt A non-classical biosynthetic route enables tocopherol synthesis in bacteria The study reports a non-classical tocopherol pathway in Rhodobacter that enables heterologous α-tocopherol synthesis by bypassing DMPBQ via a γ/β-tocopherol methyltransferase. Yang Zhang Zhizhen Li Jifeng Yuan Article 27 Jul 2026 A non-classical biosynthetic route enables tocopherol synthesis in bacteria The study reports a non-classical tocopherol pathway in Rhodobacter that enables heterologous α-tocopherol synthesis by bypassing DMPBQ via a γ/β-tocopherol methyltransferase. Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism The study employs region-specific knockout of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in either the area postrema or hypothalamus of mice to determine how GIPR agonism and antagonism regulate food intake and body weight via distinct brain regions. Jo Edward Lewis Mireia Montaner Frank Reimann Letter Open Access 24 Jul 2026 Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism The study employs region-specific knockout of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in either the area postrema or hypothalamus of mice to determine how GIPR agonism and antagonism regulate food intake and body weight via distinct brain regions. Jo Edward Lewis Mireia Montaner Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer Mitochondrial oxidative metabolism is found to strongly affect the response of colorectal cancer (CRC) cells to the chemotherapeutic drug 5-fluorouracil (5FU). Targeting mitochondrial metabolism sensitizes CRC cells to 5FU. Deborah Y. Moss Connor N. Brown Emma M. Kerr Article Open Access 23 Jul 2026 Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer Mitochondrial oxidative metabolism is found to strongly affect the response of colorectal cancer (CRC) cells to the chemotherapeutic drug 5-fluorouracil (5FU). Targeting mitochondrial metabolism sensitizes CRC cells to 5FU. Deborah Y. Moss

Connor N. Brown Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics This study demonstrates that lipids in ascites impair T cell activation through disrupting TCR dynamics, which has translational implications for adoptive T cell therapies. Erica G. Brown Ewoud B. Compeer Roddy S. O’Connor Article 22 Jul 2026 Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics This study demonstrates that lipids in ascites impair T cell activation through disrupting TCR dynamics, which has translational implications for adoptive T cell therapies. Ewoud B. Compeer Roddy S. O’Connor Latest Reviews & Analysis Cold sensing and the parabrachial nucleus The neural mechanisms integrating cold sensory input with adaptive thermoregulation remain incompletely understood. A new study published in Nature Metabolism identifies cold-activated neurons in the parabrachial nucleus as recipients of cold sensory cues, which coordinate autonomic, metabolic and behavioural cold responses and act as therapeutic targets for metabolic disorders. Óscar Freire-Agulleiro Miguel López News & Views 13 Aug 2026 Career pathways, part 20 Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities. In this instalment of our Career Pathways series, Adelheid (Heidi) Lempradl and Lauren V. Albrecht share their experiences of building independent research careers and navigating the opportunities and challenges of academia. Adelheid Lempradl Lauren V. Albrecht Viewpoint 07 Aug 2026 Palmitoylation modulates neutrophil anti-tumour function in liver metastasis How liver metastases evade immunity remains unclear. A new study published in Nature Metabolism reveals that DHHC17-driven laminin 511 palmitoylation and its subsequent secretion blunts neutrophil-mediated killing of metastatic cancer cells, uncovering a druggable immune checkpoint in the liver. Liang Zhou Jun Cui News & Views 05 Aug 2026 Short-chain fatty acids This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases. Aygul Dagbasi Mingzhu Cai Gary Frost Review Article 29 Jul 2026 Microbial catalysts unlock vitamin bioproduction The sustainable production of vitamin E in microbial cell factories has been restricted to tocotrienol derivatives. In this issue of Nature Metabolism , Zhang, Li and Cao et al. leverage non-classical enzymatic catalysts that are endogenous to Rhodobacter species to engineer a microbial chassis that produces tocopherols at gram scale. Alejandro I. Ramirez Lukas Ernst Jay D. Keasling News & Views 27 Jul 2026 Cold sensing and the parabrachial nucleus The neural mechanisms integrating cold sensory input with adaptive thermoregulation remain incompletely understood. A new study published in Nature Metabolism identifies cold-activated neurons in the parabrachial nucleus as recipients of cold sensory cues, which coordinate autonomic, metabolic and behavioural cold responses and act as therapeutic targets for metabolic disorders. Óscar Freire-Agulleiro Miguel López News & Views 13 Aug 2026 Cold sensing and the parabrachial nucleus The neural mechanisms integrating cold sensory input with adaptive thermoregulation remain incompletely understood. A new study published in Nature Metabolism identifies cold-activated neurons in the parabrachial nucleus as recipients of cold sensory cues, which coordinate autonomic, metabolic and behavioural cold responses and act as therapeutic targets for metabolic disorders. Óscar Freire-Agulleiro Career pathways, part 20 Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities. In this instalment of our Career Pathways series, Adelheid (Heidi) Lempradl and Lauren V. Albrecht share their experiences of building independent research careers and navigating the opportunities and challenges of academia. Adelheid Lempradl Lauren V. Albrecht Viewpoint 07 Aug 2026 Career pathways, part 20 Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities. In this instalment of our Career Pathways series, Adelheid (Heidi) Lempradl and Lauren V. Albrecht share their experiences of building independent research careers and navigating the opportunities and challenges of academia. Adelheid Lempradl Lauren V. Albrecht Palmitoylation modulates neutrophil anti-tumour function in liver metastasis How liver metastases evade immunity remains unclear. A new study published in Nature Metabolism reveals that DHHC17-driven laminin 511 palmitoylation and its subsequent secretion blunts neutrophil-mediated killing of metastatic cancer cells, uncovering a druggable immune checkpoint in the liver. Liang Zhou Jun Cui News & Views 05 Aug 2026 Palmitoylation modulates neutrophil anti-tumour function in liver metastasis How liver metastases evade immunity remains unclear. A new study published in Nature Metabolism reveals that DHHC17-driven laminin 511 palmitoylation and its subsequent secretion blunts neutrophil-mediated killing of metastatic cancer cells, uncovering a druggable immune checkpoint in the liver. Short-chain fatty acids This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases. Aygul Dagbasi Mingzhu Cai Gary Frost Review Article 29 Jul 2026 Short-chain fatty acids This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases. Microbial catalysts unlock vitamin bioproduction The sustainable production of vitamin E in microbial cell factories has been restricted to tocotrienol derivatives. In this issue of Nature Metabolism , Zhang, Li and Cao et al. leverage non-classical enzymatic catalysts that are endogenous to Rhodobacter species to engineer a microbial chassis that produces tocopherols at gram scale. Alejandro I. Ramirez Lukas Ernst Jay D. Keasling News & Views 27 Jul 2026 Microbial catalysts unlock vitamin bioproduction The sustainable production of vitamin E in microbial cell factories has been restricted to tocotrienol derivatives. In this issue of Nature Metabolism , Zhang, Li and Cao et al. leverage non-classical enzymatic catalysts that are endogenous to Rhodobacter species to engineer a microbial chassis that produces tocopherols at gram scale. Alejandro I. Ramirez Jay D. Keasling Ascites-derived lipid barrier at the T cell synapse Teresa Manzo News & Views 22 Jul 2026 The impact of microbial metabolites on host chromatin and epigenetic regulation Tohfa Kabir Zoe K. Lawler Leah A. Gates Perspective 21 Jul 2026 Endocrine-like regulation through brown fat-secreted microRNAs Research Briefing 16 Jul 2026 Itaconate as a paracrine brake on thermogenesis Lei-Lei Chen Dan Ye News & Views 14 Jul 2026 Ascites-derived lipid barrier at the T cell synapse Teresa Manzo News & Views 22 Jul 2026 Ascites-derived lipid barrier at the T cell synapse The impact of microbial metabolites on host chromatin and epigenetic regulation Tohfa Kabir Zoe K. Lawler Leah A. Gates Perspective 21 Jul 2026 The impact of microbial metabolites on host chromatin and epigenetic regulation Endocrine-like regulation through brown fat-secreted microRNAs Research Briefing 16 Jul 2026 Endocrine-like regulation through brown fat-secreted microRNAs Itaconate as a paracrine brake on thermogenesis Lei-Lei Chen Dan Ye News & Views 14 Jul 2026 Itaconate as a paracrine brake on thermogenesis Reclassification of basic experimental studies in humans — a case for a new publishing consensus Erik A. Richter David E. James Juleen R. Zierath Correspondence 30 Jun 2026 Reclassification of basic experimental studies in humans — a case for a new publishing consensus Erik A. Richter Juleen R. Zierath Understanding the somatic evolution of metabolic traits Somatic mutations are linked to diseases, yet their prevalence and relevance in health remain poorly defined. Technological advancements now enable us to delineate how tissue-specific somatic mutations drive adaptive metabolism across the lifespan and uncover hidden determinants of health and drivers of diseases. Radhika Khandelwal Anand Kumar Sharma Comment 16 Jun 2026 Understanding the somatic evolution of metabolic traits Somatic mutations are linked to diseases, yet their prevalence and relevance in health remain poorly defined. Technological advancements now enable us to delineate how tissue-specific somatic mutations drive adaptive metabolism across the lifespan and uncover hidden determinants of health and drivers of diseases. Radhika Khandelwal Anand Kumar Sharma Why machine learning fails at mass spectrometry for small molecules Machine learning approaches are increasingly being used to aid small-molecule structure elucidation from mass spectrometry data. Surprisingly, however, current models often fail to outperform even simple baseline methods. Here we examine why these approaches fall short and propose strategies to overcome their limitations. Ling Min Serena Khoo Regina Barzilay Comment 11 Jun 2026 Why machine learning fails at mass spectrometry for small molecules Machine learning approaches are increasingly being used to aid small-molecule structure elucidation from mass spectrometry data. Surprisingly, however, current models often fail to outperform even simple baseline methods. Here we examine why these approaches fall short and propose strategies to overcome their limitations. Ling Min Serena Khoo Regina Barzilay Metabolism as the biochemical language for mechanistic biomedical AI Artificial intelligence (AI) excels at prediction but often remains disconnected from biological mechanisms. We propose that metabolism may serve as a biochemical language through which AI systems can gain mechanistic understanding of how molecular states govern physiological function. Li Li Yujue Wang Zeping Hu Comment 04 Jun 2026 Metabolism as the biochemical language for mechanistic biomedical AI Artificial intelligence (AI) excels at prediction but often remains disconnected from biological mechanisms. We propose that metabolism may serve as a biochemical language through which AI systems can gain mechanistic understanding of how molecular states govern physiological function. Polyendocrine metabolic ovarian syndrome — a new name for an old problem The recent global consensus to rename polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) accurately reframes the condition as a lifelong, multisystemic disorder rather than a localized ovarian pathology. This transition underscores the central role of metabolic dysfunction, specifically the high prevalence of insulin resistance and hyperinsulinaemia, and has important consequences for basic and clinical research. Pawel Kordowitzki Helena Teede Comment 03 Jun 2026 Polyendocrine metabolic ovarian syndrome — a new name for an old problem The recent global consensus to rename polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) accurately reframes the condition as a lifelong, multisystemic disorder rather than a localized ovarian pathology. This transition underscores the central role of metabolic dysfunction, specifically the high prevalence of insulin resistance and hyperinsulinaemia, and has important consequences for basic and clinical research. Pawel Kordowitzki Good things come in twos Co-submissions bring together independent studies that offer complementary insights and strengthen one another, and they remain an integral part of how we support robust research at Nature Metabolism . Editorial 28 Apr 2026 Good things come in twos Co-submissions bring together independent studies that offer complementary insights and strengthen one another, and they remain an integral part of how we support robust research at Nature Metabolism . Trending - Altmetric Hyperglycosylation is a metabolic driver of Alzheimer’s disease Hyperglycosylation is a metabolic driver of Alzheimer’s disease Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism Parabrachial neurons orchestrate cold-induced homeostatic responses Parabrachial neurons orchestrate cold-induced homeostatic responses Explore articles by subject Guide to authors Editorial policies