Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Polyendocrine metabolic ovarian syndrome in pregnancy: pathophysiology and outcomes This Review explores the pathophysiology of polyendocrine metabolic ovarian syndrome, outlining current guidelines and research priorities to address knowledge gaps and inform clinical practice. Adipose tissue as a humoral–neuronal hub in metabolic regulation This Review highlights adipose humoral and neuronal pathways that operate through inter-organ communication to regulate systemic metabolism, examines how physiological and pathological contexts shape these signals, and explores emerging technologies and translational opportunities for targeting adipose networks in metabolic disease. Tadataka Tsuji Yu-Hua Tseng Review Article 12 Jun 2026 Adipose tissue as a humoral–neuronal hub in metabolic regulation This Review highlights adipose humoral and neuronal pathways that operate through inter-organ communication to regulate systemic metabolism, examines how physiological and pathological contexts shape these signals, and explores emerging technologies and translational opportunities for targeting adipose networks in metabolic disease. From bench to bedside: the evolving role of iodine in thyroid cancer management Diagnosing and treating thyroid cancer often involves administering radioactive iodine, but in certain tumour types, reduced ability to take in iodine limits the efficacy of this technique. In this Review, the authors discuss how molecular aberrations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration. Vincenzo Condello Joachim N. Nilsson C. Christofer Juhlin Review Article 18 Jun 2026 From bench to bedside: the evolving role of iodine in thyroid cancer management Diagnosing and treating thyroid cancer often involves administering radioactive iodine, but in certain tumour types, reduced ability to take in iodine limits the efficacy of this technique. In this Review, the authors discuss how molecular aberrations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration. Vincenzo Condello Joachim N. Nilsson C. Christofer Juhlin Hepatic neurons and metabolically induced liver dysfunction Growing evidence suggests that hepatic nerves have an important role in liver function, in both health and disease. This Review explores the contribution of the hepatic sympathetic and parasympathetic nervous systems in the development of metabolic-associated steatotic liver disease and its progression to metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma. Sally N. Pauss Kavaljit H. Chhabra Terry D. Hinds Jr. Review Article 19 Jun 2026 Hepatic neurons and metabolically induced liver dysfunction Growing evidence suggests that hepatic nerves have an important role in liver function, in both health and disease. This Review explores the contribution of the hepatic sympathetic and parasympathetic nervous systems in the development of metabolic-associated steatotic liver disease and its progression to metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma. Kavaljit H. Chhabra Terry D. Hinds Jr. Macronutrient mixtures and interactions in health and disease Increasing evidence demonstrates that the proportions, quality and balance of macronutrients in the diet influence health and disease to a greater extent than the individual effects of these macronutrients. This Review introduces a framework for navigating the complexity of macronutrient mixtures, and discusses their role in energy intake, systemic physiology, body composition and health across the life course. Stephen J. Simpson David G. Le Couteur David Raubenheimer Review Article 22 Jun 2026 Macronutrient mixtures and interactions in health and disease Increasing evidence demonstrates that the proportions, quality and balance of macronutrients in the diet influence health and disease to a greater extent than the individual effects of these macronutrients. This Review introduces a framework for navigating the complexity of macronutrient mixtures, and discusses their role in energy intake, systemic physiology, body composition and health across the life course. Stephen J. Simpson David G. Le Couteur David Raubenheimer Reframing cancer cachexia: from malnutrition to treatable disease Gaofei Wei Jose M. Garcia Maria Rohm Comment 14 Jul 2026 Reframing cancer cachexia: from malnutrition to treatable disease Oxytocin in social conflict Dayu Lin Comment 15 Jul 2026 Oxytocin in social conflict Strengthening the metabolic alliance: exercise as an essential partner of obesity pharmacotherapy Jonatan R. Ruiz Andreea Ciudin Javier Butragueño Comment 30 Jun 2026 Strengthening the metabolic alliance: exercise as an essential partner of obesity pharmacotherapy Jonatan R. Ruiz Javier Butragueño Polyendocrine metabolic ovarian syndrome in pregnancy: pathophysiology and outcomes Helena J. Teede Eszter Vanky Mahnaz Bahri Khomami Review Article 05 Jun 2026 Polyendocrine metabolic ovarian syndrome in pregnancy: pathophysiology and outcomes Helena J. Teede Mahnaz Bahri Khomami Causes and consequences of discontinuation of GLP1RAs or tirzepatide Antonio Ceriello Francesco Prattichizzo Giuseppina Tiziana Russo Review Article 21 May 2026 Causes and consequences of discontinuation of GLP1RAs or tirzepatide Antonio Ceriello Francesco Prattichizzo Giuseppina Tiziana Russo Aldosterone synthase inhibitors for the treatment of cardiovascular disease Gian Paolo Rossi Federico Bernardo Rossi Teresa Maria Seccia Review Article 22 May 2026 Aldosterone synthase inhibitors for the treatment of cardiovascular disease Gian Paolo Rossi Federico Bernardo Rossi Teresa Maria Seccia Milestone: Diabetes To mark the centenary of insulin's discovery, Nature Milestones presents a timeline of the past 100 years of diabetes research. Milestone: Diabetes To mark the centenary of insulin's discovery, Nature Milestones presents a timeline of the past 100 years of diabetes research. Collection: 20th Anniversary To celebrate the 20th anniversary of Nature Reviews Endocrinology , we have collated a collection of some of our articles from the past two decades, as well as a series of Comments discussing the past and future of endocrinology and metabolism research. Collection: 20th Anniversary To celebrate the 20th anniversary of Nature Reviews Endocrinology , we have collated a collection of some of our articles from the past two decades, as well as a series of Comments discussing the past and future of endocrinology and metabolism research. Follow us on Bluesky! Follow us for updates on the journal and news from the endocrinology and metabolism fields. Follow us on Bluesky! Follow us for updates on the journal and news from the endocrinology and metabolism fields. Article Series: Adipose tissue This Article Series includes articles on the physiology and pathophysiology of adipose tissue. Article Series: Adipose tissue This Article Series includes articles on the physiology and pathophysiology of adipose tissue. Latest Reviews & Analysis Links between bone fractures and the gut microbiota In this Review, the authors describe evidence linking the gut microbiota to bone fractures. They discuss findings from rodent models and human studies on the effects of the gut microbiota on bone and muscle and explore the mechanisms through which the gut microbiota is associated with bone fractures. Claes Ohlsson Lina Lawenius Klara Sjögren Review Article 30 Jul 2026 Therapeutic potential of targeting the orexin (hypocretin) system in sleep disorders Understanding the key mechanisms underlying sleep and wake states is essential for developing effective treatments for sleep disorders. Here, the authors discuss how the orexin (also known as hypocretin) system — a central regulator of sleep and wakefulness — is a key target in the development of treatments for sleep disorders. Birgitte R. Kornum Alberte Wollesen Breum Stine Knudsen-Heier Review Article 30 Jul 2026 Dose matters: haploinsufficiency in osteogenesis imperfecta Osteogenesis imperfecta type 1 can be caused by haploinsufficient variants of COL1A1 and can be difficult to diagnose and manage. In this Review, the authors cover the role of collagen type I haploinsufficiency in osteogenesis imperfecta type 1’s pathogenesis, treatment strategies currently under investigation and aspects of this disease that require further research. Anastasia Sclocco Wenya Yang Lidiia Zhytnik Review Article 27 Jul 2026 Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines Obesity is a chronic, adiposity-based disease with multiple, competing definitions. In the past 2 years, major professional societies have advanced new diagnostic frameworks that incorporate multimodal assessment of adiposity and its clinical consequences. In this Review, Tandar et al. evaluate contemporary anthropometric and body composition measurements, synthesize new frameworks and guidelines for the diagnosis and staging of obesity, and discuss their implications for clinical practice. Clara E. Tandar John C. Lin Fatima C. Stanford Review Article 21 Jul 2026 Nutrient and non-nutrient regulators of insulin secretion This Review explores the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors. An improved understanding of the complexities of how insulin secretion is regulated could lead to targeted treatments in the future. Jelena Kolic Noor Assaf James D. Johnson Review Article 17 Jul 2026 Links between bone fractures and the gut microbiota In this Review, the authors describe evidence linking the gut microbiota to bone fractures. They discuss findings from rodent models and human studies on the effects of the gut microbiota on bone and muscle and explore the mechanisms through which the gut microbiota is associated with bone fractures. Claes Ohlsson Lina Lawenius Klara Sjögren Review Article 30 Jul 2026 Links between bone fractures and the gut microbiota In this Review, the authors describe evidence linking the gut microbiota to bone fractures. They discuss findings from rodent models and human studies on the effects of the gut microbiota on bone and muscle and explore the mechanisms through which the gut microbiota is associated with bone fractures. Therapeutic potential of targeting the orexin (hypocretin) system in sleep disorders Understanding the key mechanisms underlying sleep and wake states is essential for developing effective treatments for sleep disorders. Here, the authors discuss how the orexin (also known as hypocretin) system — a central regulator of sleep and wakefulness — is a key target in the development of treatments for sleep disorders. Birgitte R. Kornum Alberte Wollesen Breum Stine Knudsen-Heier Review Article 30 Jul 2026 Therapeutic potential of targeting the orexin (hypocretin) system in sleep disorders Understanding the key mechanisms underlying sleep and wake states is essential for developing effective treatments for sleep disorders. Here, the authors discuss how the orexin (also known as hypocretin) system — a central regulator of sleep and wakefulness — is a key target in the development of treatments for sleep disorders. Birgitte R. Kornum

Alberte Wollesen Breum Stine Knudsen-Heier Dose matters: haploinsufficiency in osteogenesis imperfecta Osteogenesis imperfecta type 1 can be caused by haploinsufficient variants of COL1A1 and can be difficult to diagnose and manage. In this Review, the authors cover the role of collagen type I haploinsufficiency in osteogenesis imperfecta type 1’s pathogenesis, treatment strategies currently under investigation and aspects of this disease that require further research. Anastasia Sclocco Wenya Yang Lidiia Zhytnik Review Article 27 Jul 2026 Dose matters: haploinsufficiency in osteogenesis imperfecta Osteogenesis imperfecta type 1 can be caused by haploinsufficient variants of COL1A1 and can be difficult to diagnose and manage. In this Review, the authors cover the role of collagen type I haploinsufficiency in osteogenesis imperfecta type 1’s pathogenesis, treatment strategies currently under investigation and aspects of this disease that require further research. Anastasia Sclocco Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines Obesity is a chronic, adiposity-based disease with multiple, competing definitions. In the past 2 years, major professional societies have advanced new diagnostic frameworks that incorporate multimodal assessment of adiposity and its clinical consequences. In this Review, Tandar et al. evaluate contemporary anthropometric and body composition measurements, synthesize new frameworks and guidelines for the diagnosis and staging of obesity, and discuss their implications for clinical practice. Clara E. Tandar John C. Lin Fatima C. Stanford Review Article 21 Jul 2026 Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines Obesity is a chronic, adiposity-based disease with multiple, competing definitions. In the past 2 years, major professional societies have advanced new diagnostic frameworks that incorporate multimodal assessment of adiposity and its clinical consequences. In this Review, Tandar et al. evaluate contemporary anthropometric and body composition measurements, synthesize new frameworks and guidelines for the diagnosis and staging of obesity, and discuss their implications for clinical practice. Clara E. Tandar Fatima C. Stanford Nutrient and non-nutrient regulators of insulin secretion This Review explores the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors. An improved understanding of the complexities of how insulin secretion is regulated could lead to targeted treatments in the future. Jelena Kolic Noor Assaf James D. Johnson Review Article 17 Jul 2026 Nutrient and non-nutrient regulators of insulin secretion This Review explores the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors. An improved understanding of the complexities of how insulin secretion is regulated could lead to targeted treatments in the future. James D. Johnson Lipid sensing and brain hormone receptors in food intake and glucose regulation Ameth N. Garrido Sulayman Aslan Lyons Tony K. T. Lam Review Article 14 Jul 2026 Macronutrient mixtures and interactions in health and disease Stephen J. Simpson David G. Le Couteur David Raubenheimer Review Article 22 Jun 2026 Hepatic neurons and metabolically induced liver dysfunction Sally N. Pauss Kavaljit H. Chhabra Terry D. Hinds Jr. Review Article 19 Jun 2026 From bench to bedside: the evolving role of iodine in thyroid cancer management Vincenzo Condello Joachim N. Nilsson C. Christofer Juhlin Review Article 18 Jun 2026 Lipid sensing and brain hormone receptors in food intake and glucose regulation Ameth N. Garrido Sulayman Aslan Lyons Tony K. T. Lam Review Article 14 Jul 2026 Lipid sensing and brain hormone receptors in food intake and glucose regulation Ameth N. Garrido Sulayman Aslan Lyons Macronutrient mixtures and interactions in health and disease Stephen J. Simpson David G. Le Couteur David Raubenheimer Review Article 22 Jun 2026 Macronutrient mixtures and interactions in health and disease Stephen J. Simpson David G. Le Couteur David Raubenheimer Hepatic neurons and metabolically induced liver dysfunction Sally N. Pauss Kavaljit H. Chhabra Terry D. Hinds Jr. Review Article 19 Jun 2026 Hepatic neurons and metabolically induced liver dysfunction Kavaljit H. Chhabra Terry D. Hinds Jr. From bench to bedside: the evolving role of iodine in thyroid cancer management Vincenzo Condello Joachim N. Nilsson C. Christofer Juhlin Review Article 18 Jun 2026 From bench to bedside: the evolving role of iodine in thyroid cancer management Vincenzo Condello Joachim N. Nilsson C. Christofer Juhlin mRNA-LNP therapeutics for obesity: weight loss with metabolic repair Obesity involves dysfunction in metabolic tissues that is not always fully corrected by weight loss. An mRNA-lipid nanoparticle platform might offer a programmable approach for in situ production of therapeutic proteins directly in target tissues, enabling endocrine signalling, adipose remodelling and multi-pathway metabolic regulation. Jun Liao Lukas Farbiak Chuang Liu Comment 14 Aug 2026 mRNA-LNP therapeutics for obesity: weight loss with metabolic repair Obesity involves dysfunction in metabolic tissues that is not always fully corrected by weight loss. An mRNA-lipid nanoparticle platform might offer a programmable approach for in situ production of therapeutic proteins directly in target tissues, enabling endocrine signalling, adipose remodelling and multi-pathway metabolic regulation. Leadership for the postdoctoral to independent investigator transition The transition from postdoctoral researcher to independent investigator is marked by complex decision-making and uncertainty. At the Danish Diabetes and Endocrine Academy Postdoc Summit 2025, we discussed these challenges, as well as strategies to support this transition. Leonardo V. M. de Assis Richard M. Blay Thilo S. Chillon Comment 13 Aug 2026 Leadership for the postdoctoral to independent investigator transition The transition from postdoctoral researcher to independent investigator is marked by complex decision-making and uncertainty. At the Danish Diabetes and Endocrine Academy Postdoc Summit 2025, we discussed these challenges, as well as strategies to support this transition. Leonardo V. M. de Assis Richard M. Blay Thilo S. Chillon Paracrine signalling in thermogenesis Claire Greenhill Research Highlight 30 Jul 2026 Paracrine signalling in thermogenesis Claire Greenhill Anti-IL-11 treatment improves ovarian function by reducing matrix stiffness Olivia Tysoe Research Highlight 28 Jul 2026 Anti-IL-11 treatment improves ovarian function by reducing matrix stiffness Local catecholamine catabolism blunts lipolysis in ageing adipose tissue Fadi Khalaf Journal Club 28 Jul 2026 Local catecholamine catabolism blunts lipolysis in ageing adipose tissue Oxytocin in social conflict Although oxytocin is widely known as the ‘love hormone’, it is also released during social conflict, promoting acute social defence and facilitating neural circuit plasticity that heightens future social avoidance, vigilance and sensitivity to non-social stressors. Dayu Lin Comment 15 Jul 2026 Oxytocin in social conflict Although oxytocin is widely known as the ‘love hormone’, it is also released during social conflict, promoting acute social defence and facilitating neural circuit plasticity that heightens future social avoidance, vigilance and sensitivity to non-social stressors. Trending - Altmetric The role of insufficient sleep and circadian misalignment in obesity The role of insufficient sleep and circadian misalignment in obesity Muscles, exercise and obesity: skeletal muscle as a secretory organ Muscles, exercise and obesity: skeletal muscle as a secretory organ Obesity-induced and weight-loss-induced physiological factors affecting weight regain Obesity-induced and weight-loss-induced physiological factors affecting weight regain Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines Explore articles by subject Guide to authors Editorial policies