Profile Information Research Interests Life sciences / Virology / Research History Apr, 2019 - Present Senior investigator, AIDS Research Center, National Institute of Infectious Diseases 2004 - Present ：国立感染症研究所エイズ研究センター主任研究官（2007年より第３室長）（山本直樹 Nov, 2011 センター長2011年11月より俣野哲朗センター長） 2001 - 2004 年：琉球大学医学部 講師（後に助教授）（共同研究者：田中勇悦教授） 1998 - 2001 年：米国国立健康研究所 博士研究員（E. Freed 博士） 1991 - 1998 年：東京医科歯科大学医学部微生物学教室専攻生（ブリストルマーヤーズ・スクイブ研究所 （株）、生化学工業（株）研究員）（山本直樹教授） 「CXCR4阻害剤の耐性誘導とその解析」 「HIV-1複製過程におけるRab蛋白質の機能解析」 「HIV-1複製過程におけるGag蛋白質と関連宿主因子の役割の解明」 「CXCR4阻害剤KRH誘導体のマウスモデルにおける活性評価と作用機序の詳細な解析」 「HIV-1 Env蛋白質のウイルス粒子への取込機構の解明」 「CXCR4アンタゴニストT22の抗HIV活性とその作用機序の解明」 Committee Memberships 学会誌編集委員, 日本エイズ学会 Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Sayaka Boku, Masaki Kurakami, Masayuki Fujino, Takahiro Ishii, Yutaro Miura, Soshi Nishimura, Kouki Shinohara … Chemical and Pharmaceutical Bulletin, 72(1) 41-47, Jan 1, 2024 Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara … RSC Advances, 13(3) 2156-2167, 2023 Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani … Biomolecules, 11(2) 208-208, Feb 3, 2021 Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Kofi Baffour-Awuah Owusu, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura Bioorganic & Medicinal Chemistry, 30 115923-115923, Jan, 2021 Bivalent HIV-1 fusion inhibitors based on peptidomimetics Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami, Hirokazu Tamamura Bioorganic & Medicinal Chemistry, 28(24) 115812-115812, Dec, 2020 Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura Bioorganic & Medicinal Chemistry, 28(11) 115488-115488, Jun, 2020 Peer-reviewed HIV-1 matrix mutations that alter gag membrane binding modulate mature core formation and post-entry events Yuta Hikichi, Eri Takeda, Masayuki Fujino, Emi Nakayama, Tetsuro Matano, Tsutomu Murakami Virology, 532 97-107, Jun, 2019 Peer-reviewed Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors. Kobayakawa T, Ebihara K, Honda Y, Fujino M, Nomura W, Yamamoto N, Murakami T, Tamamura H Chembiochem : a European journal of chemical biology, Apr, 2019 Peer-reviewed Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. Sakyiamah MM, Kobayakawa T, Fujino M, Konno M, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H Bioorganic & medicinal chemistry, 27(6) 1130-1138, Mar 15, 2019 Peer-reviewed Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands Sakyiamah MM, Kobayakawa T, Fujino M, KonnoM, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H ChemMedChem, 8(1) 118-124, 2019 Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening Lowela Siarot, Nopporn Chutiwitoonchai, Hirotaka Sato, Hao Chang, Hironori Sato, Masayuki Fujino, Tsutomu Murakami, Toshihiro Aono, Eiichi Kodama, Kazumichi Kuroda … Biochemical and Biophysical Research Communications, 503(4) 2970-2976, Sep, 2018 Development of anti-HIV peptides based on a viral capsid protein Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura BIOPOLYMERS, 108(1), Jan, 2017 Increased HIV-1 sensitivity to neutralizing antibodies by mutations in the Env V3-coding region for resistance to CXCR4 antagonists Yuta Hikichi, Masaru Yokoyama, Taichiro Takemura, Masayuki Fujino, Sei Kumakura, Yosuke Maeda, Naoki Yamamoto, Hironori Sato, Tetsuro Matano, Tsutomu Murakami JOURNAL OF GENERAL VIROLOGY, 97(9) 2427-2440, Sep, 2016 Peer-reviewed Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura Bioorganic and Medicinal Chemistry, 23(15) 4423-4427, Jul 23, 2015 Peer-reviewed CXCR4-derived synthetic peptides inducing anti-HIV-1 antibodies Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura Bioorganic and Medicinal Chemistry, 21(22) 6878-6885, Nov 15, 2013 Peer-reviewed Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 Gene products Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Métifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi … ACS Chemical Biology, 8(10) 2235-2244, Oct 18, 2013 Peer-reviewed Anti-HIV-1 peptide derivatives based on the HIV-1 co-receptor CXCR4 Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura ChemMedChem, 8(10) 1668-1672, Oct, 2013 Peer-reviewed Multimerized CHR-derived peptides as HIV-1 fusion inhibitors Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura Bioorganic and Medicinal Chemistry, 21(15) 4452-4458, Aug 1, 2013 Peer-reviewed Cyclophilin A-Dependent Restriction to Capsid N121K Mutant Human Immunodeficiency Virus Type 1 in a Broad Range of Cell Lines Taichiro Takemura, Miyako Kawamata, Miho Urabe, Tsutomu Murakami JOURNAL OF VIROLOGY, 87(7) 4086-4090, Apr, 2013 Peer-reviewed

Single oral administration of the novel CXCR4 antagonist, KRH-3955, induces an efficient and long-lasting increase of white blood cell count in normal macaques, and prevents CD4 depletion in SHIV-infected macaques: a preliminary study Tadashi Nakasone, Sei Kumakura, Michiko Yamamoto, Tsutomu Murakami, Naoki Yamamoto MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 202(2) 175-182, Apr, 2013 Peer-reviewed Development of low molecular anti-HIV-1 agents based on HIV-1 capsid protein 町田沙穂, 小早川拓也, 横山勝, 藤野真之, 金子萌美, 倉上真樹, 朴清香, 大西立人, 小谷治, 辻耕平 … 日本薬学会年会要旨集(Web), 144th, 2024 Development of bivalent fusion inhibitors targeting HIV-1 gp41 protein 西村壮史, 小早川拓也, 辻耕平, 村上努, 玉村啓和 日本薬学会年会要旨集(Web), 144th, 2024 HIV Gagをターゲットとした創薬研究 玉村啓和, 佐藤裕徳, 横山勝, 村上努 日本エイズ学会誌, 25(4), 2023 HIV-1外被タンパク質gp41を標的とする二価型膜融合阻害剤の創製 西村壮史, 小早川拓也, 辻耕平, 村上努, 玉村啓和 日本薬学会関東支部大会講演要旨集(CD-ROM), 67th, 2023 Exploratory study on the development of HIV-1 inhibitory peptides based on an HIV-1 capsid protein 辻耕平, OWUSU Kofi Baffour-Awuah, WANG Rongyi, 小早川拓也, 村上努, 玉村啓和 日本薬学会年会要旨集(Web), 142nd, 2022 Structure-activity Relationship Studies of Small Molecule Anti-HIV-1 Agents Based on a Capsid Protein of HIV-1 岸原佑樹, 小早川拓也, 横山勝, 藤野真之, 倉上真樹, 大西立人, 朴清香, 小谷治, 辻耕平, 村上努 … メディシナルケミストリーシンポジウム講演要旨集, 39th (CD-ROM), 2022 カプシド二量体化を標的とした新規抗HIV-1低分子化合物の作用機序解析および誘導体の合成 村上努, 小早川拓也, 大西立人, 朴清香, 横山勝, 小谷治, 辻耕平, 佐藤裕徳, 玉村啓和 日本エイズ学会誌, 23(4), 2021 Elucidation of mechanism and derivative synthesis of a new anti-HIV-1 compound that targets the capsid dimerization interface 村上努, 小早川拓也, 大西立人, 朴清香, 横山勝, 小谷治, 辻耕平, 佐藤裕徳, 玉村啓和 日本ウイルス学会学術集会プログラム・予稿集(Web), 68th, 2021 カプシド二量体化を標的とした新規抗HIV-1低分子化合物の解析 村上努, 小早川拓也, 倉上真樹, 横山勝, 小谷治, 辻耕平, 佐藤裕徳, 玉村啓和 日本エイズ学会誌, 22(4), 2020 Development of a functional inhibitor for HIV-1 capsid 中山深雪, 小早川拓也, 倉上真樹, 朴清香, 横山勝, 村上努, 金子萌美, 小谷治, 佐藤裕徳, 辻耕平 … 日本薬学会年会要旨集(Web), 140th, 2020 Structure-activity relationship of small molecule inhibitor MKN-1A for HIV-1 capsid 朴清香, 小早川拓也, 倉上真樹, 中山深雪, 横山勝, 村上努, 金子萌美, 小谷治, 佐藤裕徳, 辻耕平 … 日本薬学会年会要旨集(Web), 140th, 2020 二量体化HIV-1膜融合阻害剤の作用機構 村上 努, 海老原 健人, 小早川 拓也, 藤野 真之, 児玉 栄一, 玉村 啓和 日本エイズ学会誌, 21(4) 427-427, Nov, 2019 二量体化HIV-1膜融合阻害剤の作用機序 村上努, 海老原健人, 小早川拓也, 藤野真之, 児玉栄一, 玉村啓和 日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019 HIV-1膜融合を標的とする低分子化合物を基にした二価型膜融合阻害剤の創製 海老原健人, 川田拓馬, 小早川拓也, 村上努, 玉村啓和 メディシナルケミストリーシンポジウム講演要旨集, 37th, 2019 HIV-1膜融合を標的とする低分子化合物を基にした二価型膜融合阻害剤の創製研究 海老原健人, 川田拓馬, 小早川拓也, 村上努, 玉村啓和 日本薬学会関東支部大会講演要旨集, 63rd, 2019 HIV-1カプシドタンパク質の構造を基にした新規抗HIV-1剤の構造活性相関研究 倉上真樹, 小早川拓也, 横山勝, 村上努, 金子萌美, 小谷治, 佐藤裕徳, 玉村啓和 メディシナルケミストリーシンポジウム講演要旨集, 37th, 2019 カプシドタンパク質をもとにした細胞透過性抗HIVペプチドの開発研究 王容義, 小早川拓也, 金子明美, 村上努, 玉村啓和 日本薬学会関東支部大会講演要旨集, 63rd, 2019 カプシドタンパク質をもとにした細胞透過性抗HIVペプチドの開発研究 WANG Rongyi, 小早川拓也, 金子萌美, OWUSU Kofi, 村上努, 玉村啓和 メディシナルケミストリーシンポジウム講演要旨集, 37th, 2019 二量体化に基づいた新規抗HIV-1膜融合阻害薬の創出 村上努, 海老原健人, 藤野真之, 本田柚子奈, 小早川拓也, 野村渉, 玉村啓和 日本エイズ学会誌, 20(4), 2018 Soluble Anchor Supportを用いたインテグラーゼ阻害活性を有するステープルペプチドの合成 宮木大輔, 小早川拓也, 村上努, 高橋大輔, 玉村啓和 日本薬学会関東支部大会講演要旨集, 62nd, 2018 Professional Memberships Research Projects カプシド蛋白質の二量体化を標的とした新規抗HIV薬開発に向けた基礎研究 科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025 村上 努, 玉村 啓和 高活性HIV膜融合阻害剤開発に向けた基礎的研究 科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2023 村上 努, 玉村 啓和 Molecular design strategy to avoid side effects of covalent drugs Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022 Kimura Yasuaki Analysis of viraal and host factors affecting the rapid disease progression of novel HIV variant infection. Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021 Kawahata Takuya Transplantation tolerance by regulatory immune response through innate immunity stimulation Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019 Fujino Masayuki Development of mid-size drugs based on peptidomimetic Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018 TAMAMURA Hirokazu, YOSHIMURA Kazuhisa, MURAKAMI Tsutomu Inhibition of HIV-1 by Gag peptides Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017 Murakami Tsutomu Role of Rab proteins and related host factors in HIV-1 assembly Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012 MURAKAMI Tsutomu Identification of host factors involved in HIV uncoatig Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005 MURAKAMI Tutomu, YAMAMOTO Naoki レトロウイルス増殖の分子メカニズムの解明 2004 Study on molecular mechanisms of retrovirus replication 2004 Elucidation of HIV-1 envelope incorporation into virions Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003 MURAKAMI Tsutomu, YOSHIDA Atsushi, TANAKA Yuetsu Screening & Development of new anti-HIV drugs {{coauthor.Related.last_modified}} Updated